Prolonged-release melatonin for the treatment of insomnia: targeting quality of sleep and morning alertness-Reference-Cited by-同舟云学术

Prolonged-release melatonin for the treatment of insomnia: targeting quality of sleep and morning alertness

Published:2008-02 Issue:1 Volume:4 Page:11-21
ISSN:1745-509X
Container-title:Aging Health
language:en
Short-container-title:Aging Health

Author:

Wade Alan¹,Zisapel Nava²,Lemoine Patrick³

Affiliation:

1. CPS Research, Glasgow, UK.

2. Tel Aviv University and, Neurim Pharmaceuticals Ltd, The George S. Wise Faculty of Life Sciences, Tel-Aviv 69978, Israel.

3. The Clinique Lyon-Lumière, 33 bis rue du 8 mai 1945, Meyzieu, France.

Abstract

Prolonged-release (PR) melatonin (Circadin®, Neurim Pharmaceuticals, Tel-Aviv, Israel) is a nonbenzodiazepine licensed to treat primary insomnia in patients aged 55 years and older. It exerts its effects by mimicking endogenous melatonin, a hormone which regulates sleep. PR-melatonin has been shown to be effective in improving quality of sleep and morning alertness. An oral dose of 2 mg once-daily for 3 weeks has generally been well tolerated, and does not cause ‘hangover’ effects or impair memory and psychomotor skills.

Publisher

Future Medicine Ltd

Subject

Geriatrics and Gerontology,General Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/1745509X.4.1.11

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