Corpus callosum in cognitive and sensory processing: insights into autism

Abstract

ABSTRACT  Atypical corpus callosum size and functional connectivity have been repeatedly implicated in autism spectrum disorders (ASDs). Conversely, individuals with agenesis of the corpus callosum often present with diagnostic features characteristic of autism. An emerging literature has identified genetic and environmental factors which may contribute to both ASD symptomatology and the neuroanatomic finding of altered white matter in the corpus callosum. In this review, we consider what is known about the structure and function of the corpus callosum and provide an update on research identifying corpus callosum abnormalities in individuals with ASD. We also review the literature on behaviors characteristic of autism that are observed in individuals with agenesis of the corpus callosum in an effort to identify some of the neuropathology that is likely to be associated with these behaviors. Finally, we suggest a conceptual model of ‘sensory processing inefficiency’ for future research aimed at elucidating some of the phenotypic variation in individuals with social communication challenges.