Influence of HOTAIR rs920778 and rs12826786 genetic variants on prostate cancer risk and progression-free survival-Reference-Cited by-同舟云学术

Influence of HOTAIR rs920778 and rs12826786 genetic variants on prostate cancer risk and progression-free survival

Published:2018-03 Issue:3 Volume:12 Page:257-264
ISSN:1752-0363
Container-title:Biomarkers in Medicine
language:en
Short-container-title:Biomarkers in Medicine

Author:

Oliveira Ana Isabel¹²,Xavier-Magalhães Ana¹²,Moreira-Barbosa Catarina³,Magalhães Hugo¹²,Henrique Rui³⁴⁵,Jerónimo Carmen³⁴,Costa Bruno M¹²

Affiliation:

1. Life & Health Sciences Research Institute (ICVS), School of Medicine, Campus de Gualtar, University of Minho, 4710-057 Braga, Portugal

2. ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Campus de Gualtar, University of Minho, 4710-057 Braga, Portugal

3. Cancer Biology & Epigenetics Group – Research Center CI-IPOP, Portuguese Oncology Institute of Porto, Porto, Portugal

4. Department of Pathology & Molecular Immunology, Institute of Biomedical Sciences Abel Salazar – University of Porto (ICBAS-UP), Porto, Portugal

5. Department of Pathology, Portuguese Oncology Institute of Porto (IPO Porto), Porto, Portugal

Abstract

Aim: Evaluate the impact of the single nucleotide polymorphisms rs920778 and rs12826786 in the long noncoding RNA HOTAIR in the susceptibility and prognosis of prostate cancer (PCa) patients. Patients & methods: HOTAIR single nucleotide polymorphisms were genotyped by restriction fragment length polymorphism in 151 PCa cases and 180 cancer-free controls. Odds ratio, 95% CIs and prognostic significance were calculated. Results: Our data showed no statistically significant associations between HOTAIR polymorphic variants in rs920778 and rs12826786 and PCa susceptibility. However, the CC genotype in rs12826786 was significantly associated with shorter biochemical recurrence-free survival in pT3-stage PCa patients. Conclusion: Our results indicate that HOTAIR rs12826786 CC genotype may be an independent prognostic biomarker in a particular subset of PCa tumors.

Publisher

Future Medicine Ltd

Subject

Biochemistry, medical,Clinical Biochemistry,Drug Discovery

Link

https://www.futuremedicine.com/doi/pdf/10.2217/bmm-2017-0258

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