Inflammatory biomarker in adipose stem cells of women with endometrial cancer-Reference-Cited by-同舟云学术

Inflammatory biomarker in adipose stem cells of women with endometrial cancer

Published:2018-09 Issue:9 Volume:12 Page:945-952
ISSN:1752-0363
Container-title:Biomarkers in Medicine
language:en
Short-container-title:Biomarkers in Medicine

Author:

Linkov Faina¹²³,Goughnour Sharon L¹,Adambekov Shalkar²,Lokshin Anna⁴,Kelley Joseph L⁵,Sukumvanich Paniti⁵,Comerci John T⁵,Marra Kacey G⁶,Kokai Lauren E⁶,Rubin J Peter⁶,Vlad Anda M¹,Philips Brian J¹,Edwards Robert P¹³

Affiliation:

1. Department of Obstetrics, Gynecology, & Reproductive Sciences, Magee-Womens Research Institute, University of Pittsburgh, 3380 Blvd of the Allies, Pittsburgh, PA 15213, USA

2. Department of Epidemiology, University of Pittsburgh, 130 De Soto Street, Pittsburgh, PA 15216, USA

3. UPMC Hillman Cancer Center, 5115 Centre Avenue Pittsburgh, PA 15232, USA

4. Department of Medicine, UPMC Cancer Pavilion, 5150 Centre Avenue, Pittsburgh, PA 15232, USA

5. Division of Gynecologic Oncology, Department of Obstetrics, Gynecology & Reproductive Sciences, University of Pittsburgh School of Medicine, Magee-Womens Hospital, 300 Halket Street, Pittsburgh, PA 15213, USA

6. Department of Plastic Surgery, University of Pittsburgh School of Medicine, 3550 Terrace Street, Scaife Hall, Pittsburgh, PA 15261, USA

Abstract

Aim: To explore inflammatory biomarkers secreted by adipose stem cells (ASCs) in omental, retroperitoneal and subcutaneous adipose tissues of women with endometrial cancer. Patients & Methods: ASCs were collected from 22 women, aged 35-83 years, undergoing hysterectomy for endometrial cancer. Angiopoietin-2, EGF, IL-8, leptin, VEGFA, VEGFC and VEFGD levels in the ASC-conditioned media were analyzed by Luminex. Results: We found a significant difference between the three depots for IL-8 (p < 0.0001), with the highest levels of IL-8 in the omental depot. VEGFA levels were highest in the retroperitoneal depot. Conclusion: This is one of the first studies to explore biomarker expression in ASC-conditioned media in adipose tissue. ASC characteristics may be important to evaluate in relation to cancer risk.

Publisher

Future Medicine Ltd

Subject

Biochemistry (medical),Clinical Biochemistry,Drug Discovery

Link

https://www.futuremedicine.com/doi/pdf/10.2217/bmm-2017-0355

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