Cancer-type OATP1B3 mRNA has the potential to become a detection and prognostic biomarker for human colorectal cancer-Reference-Cited by-同舟云学术

Cancer-type OATP1B3 mRNA has the potential to become a detection and prognostic biomarker for human colorectal cancer

Published:2017-08 Issue:8 Volume:11 Page:629-639
ISSN:1752-0363
Container-title:Biomarkers in Medicine
language:en
Short-container-title:Biomarkers in Medicine

Author:

Sun Yuchen¹,Harada Manami¹,Shimozato Osamu²,Souda Hiroaki³,Takiguchi Nobuhiro³,Nabeya Yoshihiro³,Kamijo Takehiko⁴,Akita Hidetaka¹,Anzai Naohiko⁵,Chiba Kan¹,Furihata Tomomi¹⁵

Affiliation:

1. Laboratory of Pharmacology & Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan

2. Laboratory of DNA Damage Signaling, Chiba Cancer Center Research Institute, Chiba, Japan

3. Department of Gastrointestinal Surgery, Chiba Cancer Center, Chiba, Japan

4. Research Institute for Clinical Oncology, Saitama Cancer Center, Saitama, Japan

5. Department of Pharmacology, Graduate School of Medicine, Chiba University, Chiba, Japan

Abstract

Aim: We aimed to clarify diagnostic and prognostic biomarker potentials of cancer-type organic anion transporting polypeptide 1B3 (Ct-OATP1B3) mRNA in colorectal cancer (CRC) patients. Patients & methods: Ct-OATP1B3 mRNA levels in 97 CRC and adjacent normal colon tissues were measured by real-time PCR. The receiver operating characteristic curve analysis and the Kaplan–Meier curve analysis were performed to characterize its biomarker potentials. Results: Ct-OATP1B3 mRNA showed noticeable diagnostic power (the area under the receiver operating characteristic = 0.91) in the CRC patients. Additionally, the higher/lower mRNA expression was clearly associated with better/poorer overall survival in the CRC patients (p < 0.05). Conclusion: Ct-OATP1B3 mRNA has the potential to be a tissue-based biomarker for definitive diagnosis and prognostic stratification in CRC.

Publisher

Future Medicine Ltd

Subject

Biochemistry (medical),Clinical Biochemistry,Drug Discovery

Link

https://www.futuremedicine.com/doi/pdf/10.2217/bmm-2017-0098

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