Presence of microsatellite instability in esophageal squamous cell carcinoma associated with chagasic megaesophagus-Reference-Cited by-同舟云学术

Presence of microsatellite instability in esophageal squamous cell carcinoma associated with chagasic megaesophagus

Published:2018-06 Issue:6 Volume:12 Page:573-582
ISSN:1752-0363
Container-title:Biomarkers in Medicine
language:en
Short-container-title:Biomarkers in Medicine

Author:

Campanella Nathália C¹,Lacerda Croider Franco¹²,Berardinelli Gustavo Noriz¹,Abrahão-Machado Lucas Faria³,Cruvinel-Carloni Adriana¹,De Oliveira Antônio Talvane Torres²,Scapulatempo-Neto Cristovam¹³,Crema Eduardo⁴,Adad Sheila Jorge⁴,Rodrigues Maria Aparecida Marchesan⁵,Henry Maria Aparecida Coelho Arruda⁵,Guimarães Denise Peixoto¹⁶,Reis Rui Manuel¹⁷⁸

Affiliation:

1. Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, Brazil

2. Department of Digestive Surgery, Barretos Cancer Hospital, Barretos, São Paulo, Brazil

3. Department of Pathology & Molecular Diagnostics, Barretos Cancer Hospital, Barretos, São Paulo, Brazil

4. Department of Digestive Surgery & Pathology, Medical School, UFTM -Federal University of Triângulo Mineiro, Uberaba, Minas Gerais, Brazil

5. Department of Gastroenterology Surgery & Pathology, Medical School, UNESP - São Paulo State University, Botucatu, São Paulo, Brazil

6. Department of Endoscopy, Barretos Cancer Hospital, Barretos, São Paulo, Brazil

7. Life & Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal

8. ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal

Abstract

Aim: The molecular pathogenesis of esophageal squamous cell carcinoma (ESCC) has been increasingly studied, but there is no report on the role of MSI in ESCC development associated with chagasic megaesophagus (CM).Results/methodology: In four ESCC/CM (4/19) we found microsatellite instability (MSI) alterations (21.1%), being three MSI-L (15.8%) and one MSI-H (5.3%). Four out of 35 ESCC cases showed MSI-L (11.4%) and only one out of 26 CM cases presented MSI-L (3.9%). The MSI-H was observed in an ESCC/CM patient that presents lack of MSH6 immunostaining corroborating deficiency in MMR pathway. Interestingly, the MSI-H ESCC/CM case also presented a deletion the HSP110 poly(T)17 gene. Discussion/conclusion: Taking together, we concluded that MSI is a rare event in esophageal squamous cell carcinoma, but can be associated with CM.

Publisher

Future Medicine Ltd

Subject

Biochemistry (medical),Clinical Biochemistry,Drug Discovery

Link

https://www.futuremedicine.com/doi/pdf/10.2217/bmm-2017-0329

Reference36 articles.

1. Oesophageal carcinoma

2. Worldwide incidence, mortality and time trends for cancer of the oesophagus

3. Carcinoma of the esophagus as a complication of megaesophagus

4. Achalasia and squamous cell carcinoma of the esophagus: Analysis of 241 patients

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