FABP4 as a biomarker for knee osteoarthritis-Reference-Cited by-同舟云学术

FABP4 as a biomarker for knee osteoarthritis

Published:2018-02 Issue:2 Volume:12 Page:107-118
ISSN:1752-0363
Container-title:Biomarkers in Medicine
language:en
Short-container-title:Biomarkers in Medicine

Author:

Zhang Chaofan¹²,Li Teng¹,Chiu Kwong Yuen¹,Wen Chunyi³,Xu Aimin⁴⁵⁶,Yan Chun Hoi¹⁷

Affiliation:

1. Department of Orthopaedics & Traumatology, The University of Hong Kong, Hong Kong SAR 999077, PR China

2. Department of Orthopedics, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350004, PR China

3. Interdisciplinary Division of Biomedical Engineering, Faculty of Engineering, Hong Kong Polytechnic University, Hong Kong SAR 999077, PR China

4. State Key Laboratory of Pharmaceutical Biotechnology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong 999077, PR China

5. Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong 999077, PR China

6. Department of Pharmacology & Pharmacy, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong 999077, PR China

7. Shenzhen Key Laboratory for Innovative Technology in Orthopaedic Trauma, Department of Orthopaedics & Traumatology, The University of Hong Kong-Shenzhen Hospital, Shenzhen 518000, PR China

Abstract

Aim: To explore the role of an adipokine-termed fatty acid-binding protein 4 (FABP4) in osteoarthritis (OA). Methods: Patients with primary knee OA and non-OA controls were included. Paired tissues including plasma, synovial fluid (SF), subcutaneous fat and infrapatellar fat pad (IPFP) were harvested during surgery. FABP4 concentration was determined by ELISA. Results: Plasma FABP4 increased significantly with OA stage (n = 263). OA patients (n = 38) had significantly higher plasma and SF FABP4 than non-OA patients (n = 29). FABP4 level of IPFP was positively correlated with SF FABP4. Conclusion: OA patients had significantly high systemic and local FABP4, and IPFP may be the main source of FABP4 in synovial cavity. FABP4 may be a promising biomarker for OA.

Publisher

Future Medicine Ltd

Subject

Biochemistry, medical,Clinical Biochemistry,Drug Discovery

Link

https://www.futuremedicine.com/doi/pdf/10.2217/bmm-2017-0207

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