Compound heterozygous MTHFR (C677T and A1298C) variants and anterior STEMI: cause or bystander?-Reference-Cited by-同舟云学术

Compound heterozygous MTHFR (C677T and A1298C) variants and anterior STEMI: cause or bystander?

Published:2021-08 Issue:5 Volume:17 Page:841-845
ISSN:1479-6678
Container-title:Future Cardiology
language:en
Short-container-title:Future Cardiology

Author:

Bazmpani Maria Anna¹^ORCID,Karvounis Haralambos¹,Kassimis George¹²^ORCID

Affiliation:

1. First Department of Cardiology, Aristotle University of Thessaloniki, AHEPA University Hospital, Thessaloniki, Greece

2. Second Department of Cardiology, Hippokration Hospital, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece

Abstract

We present the case of a 40-year-old female patient with ST-segment elevation myocardial infarction successfully treated with a primary percutaneous coronary intervention. Thrombophilia testing revealed compound heterozygous MTHFR (C677T and A1298C) variants. We searched the literature for myocardial infarction in the setting of MTHFR polymorphisms and the possible pathophysiologic mechanisms. In young patients presenting with a thrombotic event, screening for thrombophilia could be beneficial for identification of etiology.

Publisher

Future Medicine Ltd

Subject

Cardiology and Cardiovascular Medicine,Molecular Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fca-2020-0144

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