Macitentan in the treatment of pulmonary arterial hypertension

Author:

Zebadúa Rodrigo1,Hernández-Pérez Andrea Priscila1,García Antonio1,Zayas Nayeli1,Sandoval Julio1,López Julio1,Pulido Tomás1ORCID

Affiliation:

1. Cardiopulmonary Department, National Heart Institute, Mexico City, Mexico

Abstract

Pulmonary arterial hypertension (PAH) is an uncommon but lethal and progressive disease in which prostacyclin, nitric oxide and endothelin-1 pathways are disturbed and contribute to the pathophysiology of this disease. Endothelin receptor antagonists are a class of drugs that have been approved as PAH therapy. Macitentan is a lipophilic, tissue specific, dual receptor antagonist with a higher potency than bosentan and a reduced risk of hepatic injury. Macitentan has shown a reduction in morbidity and mortality due to PAH at long-term follow-up and improvements in hemodynamics, exercise capacity and functional class at the short term. Its main adverse events are nasopharyngitis, bronchitis and an increased risk of anemia. We review the clinical data of macitentan and its use in PAH.

Publisher

Future Medicine Ltd

Subject

Cardiology and Cardiovascular Medicine,Molecular Medicine

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