The effects of CYP2C9 and VKORC1 gene polymorphisms on warfarin maintenance dose in Turkish cardiac patients

Author:

Akdeniz Cansu Selcan1,Cevik Mehtap2,Canbolat Ismail Polat1,Yurdakul Selen1,Cagatay Penbe3,Ciftci Cavlan1,Karaalp Atila4ORCID,Susleyici Belgin2ORCID

Affiliation:

1. Department of Cardiology, Demiroglu Bilim University Faculty of Medicine, Istanbul, Turkey

2. Department of Molecular Biology, Marmara University Faculty of Science & Letters, Istanbul, Turkey

3. Vocational School of Health Service, Department of Medical Services & Technics, Istanbul University - Cerrahpasa, Istanbul, Turkey

4. Department of Medical Pharmacology, Marmara University School of Medicine, Istanbul, Turkey

Abstract

Aim: Our aim was to examine the effect of CYP2C9 and VKORC1 polymorphisms on warfarin dose requirements in Turkish patients. Materials & methods: 24 warfarin prescribed patients were included and analyzed for eight VKORC1 and 6 CYP2C9 polymorphisms in the study. Results: Patients with CYP2C9 *1/*1 and VKORC1 -1639 GG and GA genotypes required higher warfarin doses in comparison to wild type VKORC1 genotype. Patients with CYP2C9 *1/*3 and VKORC1 -1639 GG genotypes simultaneously, required the lowest dose of warfarin (4.64 mg/day). Patients with CYP2C9 *1/*1 and VKORC1 9041 AA genotype were found to require higher warfarin doses. Conclusion: Our results provide additional evidence to support the hypothesis that CYP2C9 *2, *3, VKORC1 9041 G > A polymorphisms explain considerable proportion of inter-individual variability in warfarin dose requirement.

Publisher

Future Medicine Ltd

Subject

Cardiology and Cardiovascular Medicine,Molecular Medicine

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