Genetic variants of methionine metabolism and DNA methylation-Reference-Cited by-同舟云学术

Genetic variants of methionine metabolism and DNA methylation

Published:2014-12 Issue:6 Volume:6 Page:585-591
ISSN:1750-1911
Container-title:Epigenomics
language:en
Short-container-title:Epigenomics

Author:

Bleich Stefan¹,Semmler Alexander²,Frieling Helge¹,Thumfart L¹,Muschler Marc¹,Hillemacher Thomas¹,Kornhuber Johannes¹,Kallweit Ulf²,Simon Matthias³,Linnebank Michael²

Affiliation:

1. Molecular Neuroscience Laboratory, Department of Psychiatry, Social Psychiatry & Psychotherapy, Hannover Medical School, Hannover, Germany

2. Department of Neurology, University Hospital Zurich, Frauenklinikstrasse 26, 8091 Zurich, Switzerland

3. Department of Neurosurgery, University Hospital Bonn, Bonn, Germany

Abstract

Aim: Altered DNA methylation is associated with important and common pathologies such as cancer. The origin of altered DNA methylation is unknown. The methyl groups for DNA methylation are provided by methionine metabolism. This metabolism is characterized by a high interindividual variability, which is in part explained by genetic variants. Methods: In a cohort of 313 individuals derived from a family-based study with index cases of cerebrovascular disease, we analyzed whether global methylation of leukocyte DNA was associated with age, gender, homocysteine plasma levels or functionally relevant genetic variants. Results: We observed an association of the G-allele of the methionine synthase variant c.2756A>G (D919G) with global methylation (% methylation ± 1 SD, AA: 41.3 ± 14.9; AG: 36.4 ± 18.2; GG: 30.8 ± 16.9; F = 4.799; p = 0.009). The methionine synthase variant c.2756A>G is associated with various types of cancer. Conclusion: Our data suggest that an impact on DNA methylation may contribute to the clinical relevance of the methionine synthase variant.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Genetics

Link

https://www.futuremedicine.com/doi/pdf/10.2217/epi.14.54

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