Comparative effectiveness research for prostate cancer radiation therapy: current status and future directions

Author:

Shen Xinglei1,Zaorsky Nicholas G1,Mishra Mark V1,Foley Kathleen A2,Hyslop Terry3,Hegarty Sarah3,Pizzi Laura T4,Dicker Adam P1,Showalter Timothy N5

Affiliation:

1. Department of Radiation Oncology, Kimmel Cancer Center & Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA, USA

2. Thomson Reuters Healthcare, Cambridge, MA, USA

3. Division of Biostatistics, Department of Pharmacology & Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA, USA

4. School of Pharmacy, Thomas Jefferson University, Philadelphia, PA, USA

5. Kimmel Cancer Center & Jefferson Medical College, Thomas Jefferson University, 111 S 11th Street, Bodine Center for Cancer Treatment, Philadelphia, PA 19107, USA.

Abstract

Comparative effectiveness research aims to help clinicians, patients and policymakers make informed treatment decisions under real-world conditions. Prostate cancer patients have multiple treatment options, including active surveillance, androgen deprivation therapy, surgery and multiple modalities of radiation therapy. Technological innovations in radiation therapy for prostate cancer have been rapidly adopted into clinical practice despite relatively limited evidence for effectiveness showing the benefit for one modality over another. Comparative effectiveness research has become an essential component of prostate cancer research to help define the benefits, risks and effectiveness of the different radiation therapy modalities currently in use for prostate cancer treatment.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

Reference141 articles.

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