Epigenetics in endometrial carcinogenesis – part 2: histone modifications, chromatin remodeling and noncoding RNAs-Reference-Cited by-同舟云学术

Epigenetics in endometrial carcinogenesis – part 2: histone modifications, chromatin remodeling and noncoding RNAs

Published:2017-06 Issue:6 Volume:9 Page:873-892
ISSN:1750-1911
Container-title:Epigenomics
language:en
Short-container-title:Epigenomics

Author:

Bartosch Carla¹²³⁴,Lopes José Manuel³⁵⁶,Jerónimo Carmen²⁴⁷

Affiliation:

1. Department of Pathology, Portuguese Oncology Institute of Porto (IPO-Porto), Porto, Portugal

2. Cancer Biology & Epigenetics Group, Research Center (CI-IPOP), Portuguese Oncology Institute of Porto, Porto, Portugal

3. Department of Pathology & Oncology, Medical Faculty, University of Porto, Porto, Portugal

4. Porto Comprehensive Cancer Center (P.ccc), Porto, Portugal

5. Department of Pathology, Centro Hospitalar São João (CHSJ), Porto, Portugal

6. IPATIMUP (Institute of Molecular Pathology & Immunology, University of Porto); I3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal

7. Department of Pathology & Molecular Immunology, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal

Abstract

Carcinogenesis is a multistep multifactorial process that involves the accumulation of genetic and epigenetic alterations. In the past two decades, there has been an exponential growth of knowledge establishing the importance of epigenetic changes in cancer. Our work focused on reviewing the main role of epigenetics in the pathogenesis of endometrial carcinoma, highlighting the reported results concerning each epigenetic mechanistic layer. In a previous review, we assessed DNA methylation alterations. The present review examines the contribution of histone modifications, chromatin remodeling and noncoding RNA alterations for endometrial carcinogenesis.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Genetics

Link

https://www.futuremedicine.com/doi/pdf/10.2217/epi-2016-0167

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