Epigenetic regulation of axonal regenerative capacity-Reference-Cited by-全球学者库

Epigenetic regulation of axonal regenerative capacity

Published:2016-10 Issue:10 Volume:8 Page:1429-1442
ISSN:1750-1911
Container-title:Epigenomics
language:en
Short-container-title:Epigenomics

Author:

Weng Yi-Lan¹²,Joseph Jessica¹³,An Ran¹²,Song Hongjun¹²³⁴,Ming Guo-li¹²³⁴⁵

Affiliation:

1. Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

2. Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

3. Graduate Program in Cellular & Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

4. The Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

5. Department of Psychiatry & Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

Abstract

The intrinsic growth capacity of neurons in the CNS declines during neuronal maturation, while neurons in the adult PNS are capable of regeneration. Injured mature PNS neurons require activation of an array of regeneration-associated genes to regain axonal growth competence. Accumulating evidence indicates a pivotal role of epigenetic mechanisms in transcriptional reprogramming and regulation of neuronal growth ability upon injury. In this review, we summarize the latest findings implicating epigenetic mechanisms, including histone and DNA modifications, in axon regeneration and discuss differential epigenomic configurations between neurons in the adult mammalian CNS and PNS.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Genetics

Link

https://www.futuremedicine.com/doi/pdf/10.2217/epi-2016-0058

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