Epigenetic alterations in rheumatoid arthritis fibroblast-like synoviocytes-Reference-Cited by-同舟云学术

Epigenetic alterations in rheumatoid arthritis fibroblast-like synoviocytes

Published:2017-04 Issue:4 Volume:9 Page:479-492
ISSN:1750-1911
Container-title:Epigenomics
language:en
Short-container-title:Epigenomics

Author:

Doody Karen M¹,Bottini Nunzio²,Firestein Gary S²

Affiliation:

1. Grenfell Campus, Memorial University of Newfoundland, Corner Brook, Newfoundland, Canada

2. Division of Rheumatology, Allergy & Immunology, University of California, San Diego School of Medicine, La Jolla, CA, USA

Abstract

Rheumatoid arthritis is an immune-mediated disease that primarily affects diarthrodial joints. Susceptibility and severity of this disease are influenced by nongenetic factors, such as environmental stress, suggesting an important role of epigenetic changes. In this review, we summarize the epigenetic changes (DNA methylation, histone modification and miRNA expression) in fibroblast-like synoviocytes, which are the joint-lining mesenchymal cells that play an important role in joint inflammation and damage. We also review the effects of these epigenetic changes on rheumatoid arthritis pathogenesis and discuss their therapeutic potential.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Genetics

Link

https://www.futuremedicine.com/doi/pdf/10.2217/epi-2016-0151

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