Weight Gain After Oophorectomy Among Women with a BRCA1 or BRCA2 Mutation-Reference-Cited by-同舟云学术

Weight Gain After Oophorectomy Among Women with a BRCA1 or BRCA2 Mutation

Published:2015-07 Issue:4 Volume:11 Page:453-459
ISSN:1745-5065
Container-title:Women's Health
language:en
Short-container-title:Womens Health (Lond Engl)

Author:

Kotsopoulos Joanne¹,Lubinski Jan²,Neuhausen Susan L³,Gronwald Jacek²,Lynch Henry T⁴,Huzarski Tomasz²,Demsky Rochelle⁵,Foulkes William D⁶,Senter Leigha⁷,Friedman Susan⁸,Ainsworth Peter⁹,Sun Ping¹,Narod Steven A¹

Affiliation:

1. Women's College Research Institute, 790 Bay Street, Room 750, Toronto, ON, M5G 1N8, Canada

2. Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland

3. City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010, USA

4. Department of Preventive Medicine & Public Health, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA

5. Division of Gynecologic Oncology, Department of Obstetrics & Gynecology, University of Toronto, 123 Edward St, Toronto, ON, M5G 1E2, Canada

6. Program in Cancer Genetics, Department of Oncology & Human Genetics, McGill University, 3755 Côte Ste-Catherine, Montreal, QC, H3T 1E2, Canada

7. Division of Human Genetics, The Ohio State University Medical Center, Comprehensive Cancer Center, 460 W 10th Avenue, Columbus, OH 43210, USA

8. Moffitt Cancer Center, Departments of Cancer Epidemiology, Biostatistics, Anatomic Pathology, & Experimental Therapeutics, 12902 Magnolia Drive, Tampa, FL 33612, USA

9. London Regional Cancer Program, 800 Commissioners Road East, London, ON, N6A 5W9, Canada

Abstract

Aim: To measure weight gain among unaffected women with a BRCA1 or BRCA2 mutation after undergoing an oophorectomy. Patients & methods: We compared the bodyweight of women with (n = 405) and without an oophorectomy (n = 741) at baseline as well as the rate of weight change prior to and following surgery among 1454 BRCA mutation carriers who had an oophorectomy. Results: There was a small and non-significant difference in bodyweight between BRCA mutation carriers who had an oophorectomy compared with those women who did not (151.5 vs 149.1 pounds; p = 0.26). There was an increase in bodyweight with increasing age, but this relationship did not differ prior to and following surgery (p comparing the slope parameters = 0.78). Conclusion: Oophorectomy is not associated with significant weight gain in high-risk women.

Publisher

SAGE Publications

Subject

General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.2217/WHE.15.4

Reference37 articles.

1. Average Risks of Breast and Ovarian Cancer Associated with BRCA1 or BRCA2 Mutations Detected in Case Series Unselected for Family History: A Combined Analysis of 22 Studies

2. Cancer Risks for BRCA1 and BRCA2 Mutation Carriers: Results From Prospective Analysis of EMBRACE

3. Impact of Oophorectomy on Cancer Incidence and Mortality in Women With a BRCA1 or BRCA2 Mutation

4. Genetic/Familial High-Risk Assessment: Breast and Ovarian, Version 1.2014

5. The impact of prophylactic salpingo-oophorectomy on menopausal symptoms and sexual function in women who carry a BRCA mutation

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. WHAM—A Prospective Study of Weight and Body Composition After Risk-Reducing Bilateral Salpingo-oophorectomy;The Journal of Clinical Endocrinology & Metabolism;2023-07-06

2. Gonadectomy in Mito-Ob mice revealed a sex-dimorphic relationship between prohibitin and sex steroids in adipose tissue biology and glucose homeostasis;Biology of Sex Differences;2018-08-29