Advances in bioelectronic medicine: noninvasive electrical, ultrasound and magnetic nerve stimulation

Author:

Fritz Jason R1,Huston Jared M123

Affiliation:

1. Institute of Bioelectronic Medicine, The Feinstein Institutes for Medical Research, Northwell Health, 350 Community Drive, Manhasset, NY 11030, USA

2. Department of Science Education, Donald & Barbara Zucker School of Medicine at Hofstra/Northwell, 500 Hofstra Boulevard, Hempstead, NY 11549, USA

3. Department of Surgery, Northwell Health, 300 Community Drive, Manhasset, NY 11030, USA

Abstract

The mammalian nervous system has evolved over millions of years to protect the host. Harnessing neural pathways for therapeutic purposes is postulated to enhance treatment specificity and minimize adverse reactions. Bioelectronic medicine aims to diagnose and treat diseases through devices that regulate electrical signaling within the nervous system. Traditionally, this was accomplished via surgical implantation of electrical pulse generators directly onto peripheral nerves. While efficacious, this approach has significant limitations, including complications and associated costs of surgical procedures, and practical issues with treating acute onset and/or short-lived diseases with invasive approaches. Novel stimulation paradigms are currently under development to overcome these clinical challenges and ultimately expand the therapeutic potential of bioelectronic medicine. Here we review noninvasive electrical, ultrasound and magnetic nerve stimulation strategies in the context of more invasive electrical therapies, and discuss their potential impact on the field of bioelectronic medicine.

Publisher

Future Medicine Ltd

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Biomaterials-based bioengineering strategies for bioelectronic medicine;Materials Science and Engineering: R: Reports;2021-10

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