Clinical significance of IL-2 and IL-10 gene polymorphisms and serum levels in patients with basal-cell carcinoma-Reference-Cited by-同舟云学术

Clinical significance of IL-2 and IL-10 gene polymorphisms and serum levels in patients with basal-cell carcinoma

Published:2016-02 Issue:2 Volume:10 Page:185-195
ISSN:1752-0363
Container-title:Biomarkers in Medicine
language:en
Short-container-title:Biomarkers in Medicine

Author:

Sobjanek Michał¹,Zabłotna Monika¹,Bień Ewa²,Gleń Jolanta¹,Sokołowska-Wojdyło Małgorzata¹,Ruckemann-Dziurdzińska Katarzyna³,Nowicki Roman¹

Affiliation:

1. Department of Dermatology, Venereology & Allergology, Medical University of Gdansk, 7 Debinki Street, 80-952 Gdansk, Poland

2. Department of Pediatrics, Hematology & Oncology, Medical University of Gdansk, Poland

3. Department of Pathology & Experimental Rheumatology, Medical University of Gdansk, Poland

Abstract

Materials & methods: Polymorphic variants of IL-2 gene (-330 T/G and +166 G/T), IL-10 gene (-1082 G/A and -819 C/T) and serum cytokines concentrations in the group of 179 patients with BCC and 173 controls were analyzed. Results: The presence of the IL-2 -330 GG genotype or IL-10 -1082 GA increased the risk of BCC (OR 3.68) (OR 3.07). IL-10 -1082 AA or GA and IL-2 -330 GG genotype increased the risk of BCC (OR 9.63). IL-2 serum levels were significantly lower (p < 0.0004) in BCC patients while IL-10 concentration was significantly higher (p < 0.00001). Conclusion: The polymorphisms in IL-2 and IL-10 genes may contribute to BCC susceptibility and influence the clinical course of BCC in polish population.

Publisher

Future Medicine Ltd

Subject

Biochemistry, medical,Clinical Biochemistry,Drug Discovery

Link

https://www.futuremedicine.com/doi/pdf/10.2217/bmm.15.113

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