Preoperative serum lactate dehydrogenase levels in colorectal and gastric cancer: a hospital-based case

Preoperative serum lactate dehydrogenase levels in colorectal and gastric cancer: a hospital-based case–control study

Published:2013-02 Issue:1 Volume:7 Page:131-137
ISSN:1752-0363
Container-title:Biomarkers in Medicine
language:en
Short-container-title:Biomarkers in Medicine

Author:

Kostakis Ioannis D¹,Vaiopoulos Aristeidis G²,Philippou Anastassios³,Papavassiliou Athanasios G⁴,Koutsilieris Michael³,Kouraklis Gregory²

Affiliation:

1. Second Department of Propedeutic Surgery, ‘Laiko’ General Hospital, University of Athens Medical School, 11527 Athens, Greece.

2. Second Department of Propedeutic Surgery, ‘Laiko’ General Hospital, University of Athens Medical School, 11527 Athens, Greece

3. Department of Experimental Physiology, University of Athens Medical School, 11527 Athens, Greece

4. Department of Biological Chemistry, University of Athens Medical School, 11527 Athens, Greece

Abstract

Aim: To reveal correlations between serum lactate dehydrogenase (LDH) levels and various clinicopathological parameters in colorectal and gastric cancer. Materials & methods: A hospital-based case–control study was conducted by measuring serum LDH levels in 140 patients with colorectal cancer, 40 patients with gastric cancer and 20 hospital controls. Results: LDH levels did not differ between patients with colorectal or gastric cancer and hospital controls. In colorectal cancer, LDH values were significantly higher in T4, N2 and/or M1 cases, with high specificities and negative predictive values, but low sensitivities and positive predictive values. On the other hand, there were no significant associations in gastric cancer. Conclusion: Serum LDH levels are increased in T4, N2 and/or M1 colorectal cancer. Most patients with early-stage cancer have normal LDH values, whereas in advanced stages, some patients have increased LDH values and others have normal values.

Publisher

Future Medicine Ltd

Subject

Biochemistry, medical,Clinical Biochemistry,Drug Discovery

Link

https://www.futuremedicine.com/doi/pdf/10.2217/bmm.12.86

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