Altered miRNA expression in the cervix during pregnancy associated with lead and mercury exposure-Reference-Cited by-同舟云学术

Altered miRNA expression in the cervix during pregnancy associated with lead and mercury exposure

Published:2015-09 Issue:6 Volume:7 Page:885-896
ISSN:1750-1911
Container-title:Epigenomics
language:en
Short-container-title:Epigenomics

Author:

Sanders Alison P¹,Burris Heather H²,Just Allan C³,Motta Valeria⁴⁵,Amarasiriwardena Chitra¹⁴,Svensson Katherine¹,Oken Emily⁶,Solano-Gonzalez Maritsa⁷,Mercado-Garcia Adriana⁷,Pantic Ivan⁴⁸,Schwartz Joel³,Tellez-Rojo Martha M⁷,Baccarelli Andrea A³⁴,Wright Robert O¹

Affiliation:

1. Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA

2. Department of Neonatology, Beth Israel Deaconess Medical Center & Division of Newborn Medicine, Boston Children's Hospital & Harvard Medical School, 330 Brookline Ave, RO 318, Boston, MA 02215, USA

3. Department of Environmental Health, Harvard TH Chan School of Public Health, Boston, MA 02115, USA

4. Laboratory of Environmental Epigenetics, Exposure Epidemiology & Risk Program, Harvard TH Chan School of Public Health, Boston, MA 02115, USA

5. Department of Clinical Sciences & Community Health University of Milan – Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy

6. Department of Population Medicine, Harvard Medical School & Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA

7. Center for Nutrition & Health Research, National Institute of Public Health, Cuernavaca, Morelos, Mexico

8. Division of Research in Public Health, National Institute of Perinatology, Mexico City, Mexico

Abstract

Aim: Toxic metals including lead and mercury are associated with adverse pregnancy outcomes. This study aimed to assess the association between miRNA expression in the cervix during pregnancy with lead and mercury levels. Materials & methods: We obtained cervical swabs from pregnant women (n = 60) and quantified cervical miRNA expression. Women's blood lead, bone lead and toenail mercury levels were analyzed. We performed linear regression to examine the association between metal levels and expression of 74 miRNAs adjusting for covariates. Results: Seventeen miRNAs were negatively associated with toenail mercury levels, and tibial bone lead levels were associated with decreased expression of miR-575 and miR-4286. Conclusion: The findings highlight miRNAs in the human cervix as novel responders to maternal chemical exposure during pregnancy.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Genetics

Link

https://www.futuremedicine.com/doi/pdf/10.2217/epi.15.54

Reference57 articles.

1. Environmental exposures, toxicologic mechanisms, and adverse pregnancy outcomes

2. Review of epidemiologic studies of paternal occupational exposure and spontaneous abortion

3. Quality of Community Drinking Water and the Occurrence of Late Adverse Pregnancy Outcomes

4. Effects of Parental Occupational Exposure to Lead and Other Metals on Spontaneous Abortion

5. Maternal Fish Consumption, Mercury Levels, and Risk of Preterm Delivery

Cited by 49 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Blood lead levels in pregnant women and their newborn infants at an Indian teaching hospital;Journal of Family Medicine and Primary Care;2024-01

2. The interaction between miRNAs and hazardous materials;Non-coding RNA Research;2023-12

3. Epigenetics of methylmercury;NeuroToxicology;2023-07

4. Air Pollution and Its Association with Cervical Cancer: A Scoping Review;Medicine & Health;2023-06-16

5. Cervical microRNA expression and spontaneous preterm birth;American Journal of Obstetrics & Gynecology MFM;2023-01