Preliminary radiogenomic study of hepatitis B virus-related hepatocellular carcinoma: associations between MRI features and mutations-Reference-Cited by-同舟云学术

Preliminary radiogenomic study of hepatitis B virus-related hepatocellular carcinoma: associations between MRI features and mutations

Published:2023-05 Issue:3 Volume:20 Page:215-225
ISSN:1741-0541
Container-title:Personalized Medicine
language:en
Short-container-title:Personalized Medicine

Author:

Gao Shanshan¹²³⁴,Wang Feihang²³⁴,Sun Wei¹²,Qian Xianling¹²,Ji Yuan⁵,Cheng Yunfeng⁶,Wang Xiaolin²³⁴,Liu Lingxiao²³⁴,Sheng Ruofan¹⁷^ORCID,Zeng Mengsu¹²^ORCID

Affiliation:

1. Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China

2. Shanghai Institute of Medical Imaging, Fudan University, Shanghai, 200032, China

3. Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China

4. National Clinical Research Center for Interventional Medicine, Zhongshan Hospital, Fudan University, Shanghai, China

5. Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China

6. Institute of Clinical Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China

7. Department of Radiology, Zhongshan Hospital (Xiamen), Fudan University, Xiamen 361015, China

Abstract

Aim: To investigate associations between MRI features and high-frequency mutations of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). Methods: This study included 58 HCC patients who underwent contrast-enhanced MRI prior to surgical resection and genome sequencing. MRI features and mutation information were evaluated. Results: The top five most frequently mutated genes in HCC were TP53 (53.45%), TAF1 (24.14%), PDE4DIP (22.41%), ABCA13 (18.97%) and LRP1B (17.24%). Mutations in TP53 and LRP1B were associated with tumor necrosis (p = 0.035) and mosaic architecture (p = 0.015), respectively. Mutations in ABCA13 were associated with mosaic architecture (p = 0.025) and necrosis (p = 0.010). Conclusion: This preliminary radiogenomics analysis showed associations between MRI features and high-frequency mutations in HBV-related HCCs.

Funder

China Postdoctoral Science Foundation

Natural Science Foundation of Fujian Province

National Natural Science Foundation of China

Youth Fund of Zhongshan Hospital Fudan University

Shanghai Sailing Program

Shanghai Municipal Key Clinical Specialty

Natural Science Foundation of Shanghai

Publisher

Future Medicine Ltd

Subject

Pharmacology,Molecular Medicine,General Medicine