The ongoing evolution of antibody-based treatments for Ebola virus infection-Reference-Cited by-同舟云学术

The ongoing evolution of antibody-based treatments for Ebola virus infection

Published:2017-03 Issue:5 Volume:9 Page:435-450
ISSN:1750-743X
Container-title:Immunotherapy
language:en
Short-container-title:Immunotherapy

Author:

Mendoza Emelissa J¹²,Racine Trina¹³,Kobinger Gary P³⁴⁵

Affiliation:

1. Zoonotic Diseases & Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada

2. Department of Immunology, University of Manitoba, Winnipeg, MB, Canada

3. Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada

4. Department of Pathology & Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA

5. Département de Microbiologie-Infectiologie et D'immunologie, Université Laval, 2705 Boulevard Laurier, Quebec City, QC G1V4G2, Canada

Abstract

The 2014–2016 Ebola virus outbreak in West Africa was the deadliest in history, prompting the evaluation of various drug candidates, including antibody-based therapeutics for the treatment of Ebola hemorrhagic fever (EHF). Prior to 2014, only convalescent blood products from EHF survivors had been administered to newly infected individuals as a form of treatment. However, during the recent outbreak, monoclonal antibody cocktails such as ZMapp, ZMAb and MB-003 were either tested in a human clinical safety and efficacy trial or provided to some based on compassionate grounds. This review aims to discuss the evolution of antibody-based treatments for EHF, their clinical trial efficacy and the development of new antibody-based therapies currently advancing in preclinical testing.

Publisher

Future Medicine Ltd

Subject

Oncology,Immunology,Immunology and Allergy

Link

https://www.futuremedicine.com/doi/pdf/10.2217/imt-2017-0010

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