Evaluation of a new protocol for wheat desensitization in patients with wheat-induced anaphylaxis-Reference-Cited by-同舟云学术

Evaluation of a new protocol for wheat desensitization in patients with wheat-induced anaphylaxis

Published:2017-06 Issue:8 Volume:9 Page:637-645
ISSN:1750-743X
Container-title:Immunotherapy
language:en
Short-container-title:Immunotherapy

Author:

Rekabi Mahsa¹,Arshi Saba²,Bemanian Mohammad Hassan²,Rekabi Vahab³,Rajabi Abolfazl⁴,Fallahpour Morteza²,Molatefi Rasool²,Shokri Sima²,Eslami Narges²,Ahmadian Javad²,Khoshmirsafa Majid⁵,Seif Farhad⁵,Mahdaviani Seyed Alireza¹,Akbarpour Nadieh²,Nabavi Mohammad²

Affiliation:

1. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis & Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2. Department of Allergy & Clinical Immunology, Iran University of Medical Sciences, Tehran, Iran

3. Pathology & Cytogenetic Department, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

4. Department of Radiology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

5. Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

Abstract

Aim: New approaches such as oral immunotherapy (OIT) may be useful in IgE-mediated anaphylaxis to wheat. Patients & methods: 12 patients underwent OIT protocol that comprised of two phases: the first with semolina flour and the second with spaghetti. Total and specific wheat IgE were assayed by ELISA before and after OIT and 18 months later. Skin prick tests were also performed. Results: Patients successfully tolerated 50 g of wheat. The median baseline total IgE was decreased after up-dosing phase and decreased after follow-up (p < 0.01). The median baseline wheat-specific IgE was increased after up-dosing and decreased after follow-up (p < 0.001). Conclusion: The efficiency and safety of our OIT protocol were shown on wheat allergic patients but further investigation is needed.

Publisher

Future Medicine Ltd

Subject

Oncology,Immunology,Immunology and Allergy

Link

https://www.futuremedicine.com/doi/pdf/10.2217/imt-2017-0011

Reference35 articles.

1. Timing of Initial Exposure to Cereal Grains and the Risk of Wheat Allergy

2. Non-Celiac Wheat Sensitivity Is Not a New Entity

3. A critical evaluation of clinical trials in adverse reactions to foods in children

4. A critical evaluation of clinical trials in adverse reactions to foods in adults

5. The natural history of wheat allergy

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