Bibliometric analysis of N6-methyladenosine in cancer: landscapes, highlights and trending topics

Abstract

Background: N6-methyladenosine (m6A) is crucial in cancer and is being intensively studied. Aim: This bibliometric analysis seeks a broad picture of the role of m6A in cancer to guide and broaden future research. Methods: Publications were retrieved from Web of Science Core Collection and PubMed from 2000 to 2021, with keywords ‘m6A’ and ‘cancer’, and analyzed in biblioshiny and VOSviewer. Results: A total of 1013 documents were included, and China and the USA were the top countries with close collaboration. Mechanisms and predictive biomarkers of m6A regulator genes were highlighted. Cross-integration of m6A and other research hot spots, including ‘immunotherapy’, ‘hypoxia' and ‘polymorphism’, were frontiers of m6A in cancer. Conclusion: This bibliometric study offered an updated perspective on m6A in cancer.