The role of miRNA-128 in the development and progression of gastrointestinal and urogenital cancer

Author:

Al-Awsi Ghaidaa Raheem Lateef1,Jasim Saade Abdalkareem2,Fakri Mustafa Yasser3,Alhachami Firas Rahi4,Ziyadullaev Shukhrat5,Kandeel Mahmoud67,Abulkassim Roua8,Sivaraman R9,M Hameed Noora10,Mireya Romero Parra Rosario11,Karampoor Sajad12ORCID,Mirzaei Rasoul13ORCID

Affiliation:

1. Department of Radiological Techniques, Al-Mustaqbal University College, Babylon, Iraq

2. Department of Medical Laboratory Techniques, Al-maarif University College, Al-Anbar-Ramadi, Iraq

3. Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, 41001, Iraq

4. Department of Radiology, College of Health & Medical Technololgy, Al-Ayen University, Thi-Qar, Iraq

5. No. 1 Department of Internal Diseases, Vice-rector for Scientific Affairs & Innovations, Samarkand State Medical University, Amir Temur Street 18, Samarkand, Uzbekistan

6. Department of Biomedical Sciences, College of Veterinary Medicine, King Faisal University, Al-Hofuf, Al-Ahsa, 31982, Saudi Arabia

7. Department of Pharmacology, Faculty of Veterinary Medicine, Kafrelshikh University, Kafrelshikh, 33516, Egypt

8. Al-Manara College for Medical Science, Misan, Iraq

9. Department of Mathematics, Dwaraka Doss Goverdhan Doss Vaishnav College, Arumbakkam, University of Madras, Chennai, India

10. Anesthesia Techniques, Al-Nisour University College, Iraq

11. Universidad Continental, Lima, Perú

12. Gastrointestinal & Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran

13. Department of Medical Biotechnology, Venom & Biotherapeutics Molecules Lab, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran

Abstract

Increasing data have shown the significance of various miRNAs in malignancy. In this regard, parallel to its biological role in normal tissues, miRNA-128 (miR-128) has been found to play an essential immunomodulatory function in the process of cancer initiation and development. The occurrence of the aberrant expression of miR-128 in tumors and the unique properties of miRNAs raise the prospect of their use as biomarkers and the next generation of molecular anticancer therapies. The function of miR-128 in malignancies such as breast, prostate, colorectal, gastric, pancreatic, esophageal, cervical, ovarian and bladder cancers and hepatocellular carcinoma is discussed in this review. Finally, the effect of exosomal miR-128 on cancer resistance to therapeutics and cancer immunotherapy in certain malignancies is highlighted.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

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