Clinical significance of Notch pathway-associated microRNA-107 in pancreatic ductal adenocarcinoma-Reference-Cited by-同舟云学术

Clinical significance of Notch pathway-associated microRNA-107 in pancreatic ductal adenocarcinoma

Published:2023-05 Issue:14 Volume:19 Page:1003-1012
ISSN:1479-6694
Container-title:Future Oncology
language:en
Short-container-title:Future Oncology

Author:

Rashid Safoora¹^ORCID,Rashid Sumaira¹^ORCID,Das Prasenjit²^ORCID,Singh Nidhi¹^ORCID,Dash Nihar R³^ORCID,Nayak Baibaswata¹^ORCID,Sati Hem C⁴^ORCID,Chauhan Shyam S⁵^ORCID,Gupta Surabhi⁶^ORCID,Saraya Anoop¹^ORCID

Affiliation:

1. Department of Gastroenterology & HNU, All India Institute of Medical Sciences, New Delhi, 110029, India

2. Department of Pathology, All India Institute of Medical Sciences, New Delhi, 110029, India

3. Department of GI Surgery, All India Institute of Medical Sciences, New Delhi, 110029, India

4. Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, 110029, India

5. Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, 110029, India

6. Department of Reproductive Biology, All India Institute of Medical Sciences, New Delhi, 110029, India

Abstract

Background & aim: MicroRNAs associated with the Notch pathway play a critical role in the progression of pancreatic carcinoma. Our aim was to study the clinical significance of miR-107 and NOTCH2 in pancreatic ductal adenocarcinoma (PDAC). Methods: The circulating miR-107 levels in PDAC and controls were determined by qPCR. NOTCH2 protein (target) expression in tissue of PDAC, periampullary carcinoma, chronic pancreatitis and normal pancreatic tissue was assessed by immunohistochemistry. Results: The circulating miR-107 levels were found to be significantly reduced in PDAC as compared with controls. Additionally, NOTCH2 protein expression was higher in PDAC tissue as compared with controls and was clinically associated with metastasis. Conclusion: Our findings demonstrate the utility of circulating miR-107 as a potential differentiating marker in PDAC.

Funder

Department of Science and Technology, New Delhi, India

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fon-2022-0356

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