PD-L1 expression and overall survival in Asian and western patients with gastric cancer-Reference-Cited by-同舟云学术

PD-L1 expression and overall survival in Asian and western patients with gastric cancer

Published:2022-07 Issue:21 Volume:18 Page:2623-2634
ISSN:1479-6694
Container-title:Future Oncology
language:en
Short-container-title:Future Oncology

Author:

Rha Sun Young¹²^ORCID,Ku Geoffrey Y³^ORCID,Kim Hyo Song¹^ORCID,Chung Hyun Cheol¹²,Amlashi Fatemeh Ghazanfari⁴^ORCID,Maru Dipen Maheshbhai⁴^ORCID,Fein Carly A³,Tang Laura H³,Zhou Wei⁵,Wu Ting⁵,Peter Senaka A⁵^ORCID,Kelsen David P³,Ajani Jaffer A⁴^ORCID

Affiliation:

1. Yonsei Cancer Center, Yonsei University Health System, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea

2. Songdang Institute for Cancer Research, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea

3. Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065, USA

4. The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA

5. Merck & Co., Inc., 126 E. Lincoln Ave. Rahway, 07065, USA

Abstract

Aim: Data are limited on PD-L1 expression and its association with overall survival (OS) in gastric cancer (GC) patients receiving routine care in different regions. Materials & methods: In a retrospective study, PD-L1 expression was assayed using the 22C3 pharmDx on GC tumor samples collected between 2003 and 2017 at South Korean and US cancer centers. PD-L1 positivity was defined as combined positive score (CPS) ≥1. The relationship between PD-L1 and OS was analyzed. Results: Of 574 GC tumor samples, 67.4% were CPS ≥1 (68.7% in Korean and 65.7% in US patients). PD-L1 expression was not associated with OS (adjusted hazard ratio: 0.94; 95% CI: 0.75–1.17). Conclusion: PD-L1 prevalence and its association with OS was similar between South Korean and US GC patients.

Funder

Merck Sharp and Dohme

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fon-2022-0103

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