Prognostic value of GPC5 polymorphism rs2352028 and clinical characteristics in Chinese lung cancer patients

Author:

Wang Fan1ORCID,Li Yutao2,Li Zhengxing3,Zou Zixiu4,Lu Yongming5,Xu Chang6,Zhao ZongXu5,Wang HuaiZhou7,Wang Yi2,Guo Shicheng2,Jin Li2,Wang Jiucun2,Li Qiang8,Jiang GengXi9,Xia Fan10,Shen Bo11,Wu Junjie121314ORCID

Affiliation:

1. Company 1 of Basic Medical Science, Navy Military Medical University, Shanghai, 200433, China

2. State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics & Development, School of Life Sciences, Fudan University, Shanghai, 200438, China

3. Company 6 of Basic Medical Science, Navy Military Medical University, Shanghai, 200433, China

4. School of Life Sciences, Fudan University, Shanghai, 200438, China

5. Department of Biochemistry and Molecular Biology, Hainan Medical University, Haikou, 571199, China

6. Clinical College of Xiangnan University, Chenzhou, 423000, China

7. Department of Laboratory Diagnosis, Navy Military Medical University Affiliated Changhai Hospital, Shanghai, 200433, China

8. Department of Respiratory and Critical Care Medicine, Shanghai East Hospital, TongJi University, Shanghai, 200120, China

9. Department of Thoracic Surgery, Navy Military Medical University Affiliated Changhai Hospital, Shanghai, 200433, China

10. Department of Respiratory Disease, Navy 905 Hospital, Shanghai, 200235, China

11. Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Nanjing, 210009, China

12. Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China

13. Department of Pulmonary and Critical Care Medicine, Shanghai Geriatric Medical Center, Shanghai, 200032, China

14. State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, 200438, China

Abstract

Background: GPC5 rs2352028 is associated with the risk of lung cancer, but its relationship with lung cancer prognosis is unclear. Materials & methods: The authors collected blood samples from 888 patients with lung cancer and used a Cox proportional hazards model to analyze the association between prognosis and GPC5 polymorphism rs2352028. Results: GPC5 rs2352028 C > T was associated with a better prognosis. Patients with CT genotype had longer overall survival than those with CC genotype. Additionally, older and early-stage patients with CT + TT genotype had a lower risk of death than those with CC genotype. Conclusion: GPC5 rs2352028 C > T may play a protective role in patients with lung cancer and GPC5 rs2352028 may be a potential genetic marker for lung cancer prognosis.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

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