Effect of lateral lymph nodes without malignant characteristics on the prognosis of patients with rectal cancer-Reference-Cited by-同舟云学术

Effect of lateral lymph nodes without malignant characteristics on the prognosis of patients with rectal cancer

Published:2022-10 Issue:31 Volume:18 Page:3509-3518
ISSN:1479-6694
Container-title:Future Oncology
language:en
Short-container-title:Future Oncology

Author:

Zhang Chenghai¹,Cui Ming¹,Xing Jiadi¹,Yang Hong¹,Yao Zhendan¹,Zhang Nan¹,Tan Fei¹,Liu Maoxing¹,Xu Kai¹,Su Xiangqian¹^ORCID

Affiliation:

1. Key Laboratory of Carcinogenesis & Translational Research (Ministry of Education), Department of Gastrointestinal Surgery IV, Peking University Cancer Hospital & Institute, 52 Fu-Cheng Road, Hai-Dian District, Beijing, 100142, China

Abstract

Background: Lateral lymph node (LLN) metastasis is a poor prognostic factor for rectal cancer patients. However, the effect of LLNs without malignant characteristics on the prognosis of rectal cancer patients has been uncertain. Methods: Consecutive patients who underwent laparoscopic-assisted low anterior resection were included. Patients with MRI-detected LLNs, but without malignant characteristics, were compared with patients with no MRI-detected LLNs. Results: The local recurrence rate was higher in the LLN-present group than in the LLN-absent group (9.8% vs 2.5%; p = 0.056). The overall survival of patients with no MRI-detected LLNs was significantly better than that of patients with MRI-detected LLNs (p = 0.021). Conclusion: The presence of LLNs, even without malignant features, may lead to worse local control and overall survival.

Funder

Beijing Natural Science Foundation

Capital's Funds for Health Improvement and Research

National Natural Science Foundation of China

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fon-2022-0476

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