How viruses use the immune system to promote infection of polarized cells

Abstract

ABSTRACT:  To establish infection and access bodily compartments including the gut, lung, liver and brain, viruses must traverse polarized epithelial and endothelial cell sheets. Many viruses use components of the immune system to successfully infect epithelial cells and gain access to underlying tissue. Recently, several reports have highlighted new and surprising ways by which viruses can hijack the immune system to invade polarized cells. This review will summarize recent advances in our understanding of how viruses interact with the immune system, and with polarized cells, for successful infection. These studies raise important questions about the design and screening of therapeutics and vaccines that activate the immune system, which may need to consider the role of immune cells and the inflammatory microenvironment.