Advancing full length genome sequencing for human RNA viral pathogens

Author:

Djikeng Appolinaire1,Spiro David1

Affiliation:

1. Infectious Disease Group, The J Craig Venter Institute (JCVI), 9704 Medical Center Drive, Rockville, MD 20850, USA.

Abstract

In the face of numerous emerging and re-emerging viral threats, large-scale genome sequencing efforts are underway to monitor viral evolution in real-time. To fully appreciate the mechanisms of viral adaptation and evolution, and to also develop reagents and resources for a better molecular diagnosis of emerging and re-emerging viral infections, there has been an increasing effort toward producing full length viral genome sequences. To date, high-throughput platforms have been developed using traditional Sanger-based sequencing and there are currently prospects to apply next generation sequencing methods to develop an ultra high-throughput strategy for viral genome sequencing and analysis.

Publisher

Future Medicine Ltd

Subject

Virology

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