Understanding the relationship between ApoE and HSV-1 and its possible significance in Alzheimer’s disease

Abstract

Evaluation of: Miller RM, Federoff HJ: Isoform-specific effects of ApoE on HSV immediate early gene expression and establishment of latency. Neurobiol. Aging (2006) (Epub ahead of print). It is 100 years since Alzheimer's disease was first described and there is still no consensus of opinion regarding the etiology of its sporadic form. Herpes simplex virus type 1 (HSV-1), in conjunction with apolipoprotein E (ApoE), may well play a role in this form of the disease. In the evaluated article, Miller and Federoff try to determine whether the ApoE profile affects the expression of the HSV-1 immediate-early genes and the production of the virus’ latency-associated transcript. Their results show that overexpression of the intermediate-early genes and the establishment of latency are directly correlated with the ApoE genotype.