HBV X protein: elucidating a role in oncogenesis-Reference-Cited by-同舟云学术

HBV X protein: elucidating a role in oncogenesis

Published:2008-09 Issue:5 Volume:3 Page:455-470
ISSN:1746-0794
Container-title:Future Virology
language:en
Short-container-title:Future Virology

Author:

Feitelson Mark A¹,Reis Helena MGPV²,Pan Jingbo³,Clayton Marcy⁴,Sun Bill⁴,Satiroglu-Tufan N Lale⁵,Lian Zhaorui⁴

Affiliation:

1. Department of Biology, College of Science & Technology, Temple University, PA 19122, USA. and, Center for Biotechnology, College of Science & Technology, Temple University, PA 19122, USA.

2. MIT Portugal Program, Av. Antonio Jose de Almeida, 12 1000–043 Lisboa, Portugal.

3. Department of Pathology, Anatomy & Cell Biology, Thomas Jefferson University, PA 19107, USA.

4. Department of Biology, College of Science & Technology, Temple University, PA 19122, USA.

5. Department of Medical Biology, Pamukkale University School of Medicine, Kinikli Kampusu Morfoloji Binasi, 20020 Denizli, Turkey.

Abstract

Chronic HBV infection is associated with the development of hepatocellular carcinoma (HCC). HBV contributes to tumorigenesis by encoding hepatitis B x antigen (HBxAg), which is a trans-regulatory protein that appears to contribute to HCC by altering patterns of host gene expression. In this review, recent data is presented that outlines some of the putative mechanisms whereby HBxAg contributes to HCC. With the development of animal models of HBxAg-mediated HCC, the relevance and temporal order of putative steps in this process can now be dissected to elucidate what is rate limiting and when. This will have a profound impact on the design of novel and specific therapeutics for HCC.

Publisher

Future Medicine Ltd

Subject

Virology

Link

https://www.futuremedicine.com/doi/pdf/10.2217/17460794.3.5.455

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