Emergence of simian foamy viruses in humans: facts and unanswered questions

Abstract

A large proportion of viral pathogens that have emerged in humans are considered to have originated in animals. Simian viral infections of humans represent an increasing public health concern. This is well illustrated by retroviruses such as HIV-1/2 and human T-cell lymphotropic virus (HTLV)-1, which have a unique ability to cross species, adapt to a new host and spread. In this short review, we will present the currently available data on the transmission of the simian foamy retroviruses (SFVs) to humans. Indeed, recent data indicate the presence of these exogenous retroviruses, of the Spumaretrovirinae subfamily and of the Spumavirus genus, in individuals occupationally exposed to nonhuman primates (animal caretaker, veterinarian, zoo worker) and in individuals having contact with apes and monkeys, such as hunters in Central Africa. The main unanswered questions concerning the natural history of such SFVs in humans, for instance, their magnitude and geographical distribution, their interhuman transmissibility and their disease association and pathogenicity are discussed in this review.