Virus-encoded chemokines, chemokine receptors and chemokine-binding proteins: new paradigms for future therapy

Abstract

Over millions of years of coevolution with their hosts, viruses have learned the finest artifices of the immune system defense mechanisms and developed a variety of strategies for evading them. The chemokine system has been a primary target of these viral efforts because of the critical role it plays in the development of effective immune responses. Not only do chemokines control cellular recruitment at the site of infection, they also regulate the magnitude and character of the immune responses. Several viruses, and large DNA viruses in particular, have exploited the chemokine system by hijacking and reprogramming chemokine or chemokine-receptor genes, and/or secreting chemokine-binding proteins. In the past few years there has been intense investigation in this area, driven not only by the prospect of gaining a better understanding of viral-immune evasion mechanisms, but also by the possibility of targeting these molecules as part of future antiviral therapeutic approaches, as well as exploiting viral strategies of chemokine interference as novel therapies for inflammatory or neoplastic diseases.