The importance of the glucose-to-lymphocyte ratio in patients with hepatocellular carcinoma treated with sorafenib

Author:

Yılmaz Ali1ORCID,Şimşek Melih2ORCID,Hannarici Zekeriya1ORCID,Büyükbayram Mehmet E1,Bilici Mehmet1,Tekin Salim B1

Affiliation:

1. Department Of Medical Oncology, Atatürk University Faculty of Medicine, Erzurum, Turkey

2. Department Of Medical Oncology, Bezmialem Vakif University Faculty of Medicine, Istanbul, Turkey

Abstract

Aim: To show the prognostic significance of the glucose-to-lymphocyte ratio (GLR) in hepatocellular carcinoma (HCC). Patients & methods: A total of 150 patients with advanced HCC who were treated with sorafenib in our center between January 2011 and December 2019 were included in the study retrospectively. Neutrophil-to-lymphocyte ratio, systemic immune-inflammation index, lymphocyte-to-monocyte ratio, platelet-to-lymphocyte ratio, prognostic nutritional index and GLR were analyzed to assess their prognostic value using Kaplan–Meier and Cox regression analysis before and after propensity score matching (PSM). Results: In univariate analysis before and after PSM, albumin–bilirubin grade, neutrophil-to-lymphocyte ratio, systemic immune-inflammation index, lymphocyte-to-monocyte ratio, prognostic nutritional index, AFP level and GLR were found to be significantly associated with both progression-free and overall survival. In multivariate analysis before and after PSM, GLR, albumin–bilirubin grade and AFP were determined to be independent prognostic factors for progression-free and overall survival. Conclusion: The GLR prior to sorafenib treatment is a new prognostic biomarker that may predict survival in advanced HCC.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

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