Guideline conformity to the Stupp regimen in patients with newly diagnosed glioblastoma multiforme in China

Author:

Wang Yu1,Zhang Jianmin2,Li Wenbin3,Jiang Taipeng4,Qi Songtao5,Chen Zhongping6,Kang Jingbo7,Huo Lei8,Wang Yunjie9,Zhuge Qichuan10,Gao Guodong11,Wu Yuping12,Feng Hua13,Zhao Gang14,Yang Xiaopeng15,Zhao Hui16,Wang Yirong17,Yang Hui18,Kang Dezhi19,Su Jun20,Li Liang21,Jiang Chuanlu22,Li Gang23,Qiu Yongming24,Wang Weimin25,Wang Handong26,Xu Zaihua27,Zhang Liwei3,Wang Renzhi1ORCID

Affiliation:

1. Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, 100010, China

2. Department of Neurosurgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, 310009, China

3. Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, 100070, China

4. Department of Neurosurgery, Shenzhen Second People’s Hospital, 518035, China

5. Department of Neurosurgery, Nanfang Hospital Southern Medical University, 510515, China

6. Department of Neurosurgery, Sun Yat-Sen University Cancer Center, 510060, China

7. Tumor Diagnosis & Treatment Center, The Sixth Medical Center of PLA General Hospital, 100048, China

8. Department of Neurosurgery, Xiangya Hospital Central South University, 410008, China

9. Department of Neurosurgery, The First Hospital of China Medical University, 110001, China

10. Department of Neurosurgery, The First Affiliated Hospital of Wenzhou Medical University, 325000, China

11. Department of Neurosurgery, The Fourth Military University Tangdu Hospital, 710032, China

12. Department of Craniobasal Neurology, Sichuan Cancer Hospital & Institute, The Affiliated Cancer Hospital, School of Medicine, UESTC, 610041, China

13. Department of Neurosurgery, Southwest Hospital, The First Affiliated Hospital of Army Medical University, 400038, China

14. Department of Neurosurgery, The First Bethune Hospital of Jilin University, 130021, China

15. Department of Neurosurgery, People’s Hospital of Xinjiang Uygur Autonomous Region, 830001, China

16. Department of Radiotherapy, People’s Hospital of Xinjiang Uygur Autonomous Region, 830001, China

17. Department of Neurosurgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 310016, China

18. Department of Neurosurgery, Xinqiao Hospital of Army Medical University, 400037, China

19. Department of Neurosurgery, The First Affiliated Hospital of Fujian Medical University, 350005, China

20. Department of Neurosurgery, Tumor Hospital of Harbin Medical University, 150081, China

21. Department of Neurosurgery, Peking University First Hospital, 100034, China

22. Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, 150001, China

23. Department of Neurosurgery, Qilu Hospital of Shandong University, 250012, China

24. Department of Neurosurgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, 200127, China

25. Department of Neurosurgery, General Hospital of Southern Theatre Command, 510010, China

26. Department of Neurosurgery, General Hospital of Eastern Theatre Command, 210002, China

27. Department of Neurosurgery, General Hospital of Northern Theatre Command, 110840, China

Abstract

Aims: To determine how consistently Chinese glioblastoma multiforme (GBM) patients were treated according to the Stupp regimen. Patients and methods: The proportion of treatments conforming to the Stupp regimen and reasons for nonconformity were evaluated in 202 newly diagnosed GBM patients. Results: Only 15.8% of GBM patients received treatments compliant with the Stupp regimen. The main deviations were temozolomide dosages >75 mg/m2 (58/120; 48.3%) and treatment durations <42 days (84/120; 70.0%) in the concomitant phase and temozolomide dosages <150 mg/m2 (89/101; 88.1%) in the maintenance phase. Median overall survival (27.09 vs 18.21 months) and progression-free survival (14.27 vs 12.10 months) were longer in patients who received Stupp regimen-compliant treatments. Conclusion: Increased conformity to the Stupp regimen is needed for GBM patients in China.

Funder

MSD China

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

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