Methylated <i>ZNF582</i> as a triage marker for occult cervical cancer and advanced cervical intraepithelial neoplasia-Reference-Cited by-同舟云学术

Methylated ZNF582 as a triage marker for occult cervical cancer and advanced cervical intraepithelial neoplasia

Published:2022-07 Issue:23 Volume:18 Page:2583-2592
ISSN:1479-6694
Container-title:Future Oncology
language:en
Short-container-title:Future Oncology

Author:

Su Yuehui¹,Tang Yujie¹,Zhang Ting¹,Xu Yue²,Zhang Yingcui¹,Shen Yan¹,Qin Lihong¹,Zhang Luoman¹,Cao Lili¹,Zhou Yingying¹,Liou Yuligh³,Zhang Mengzhen¹^ORCID

Affiliation:

1. Gynecology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

2. Pathology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

3. Xiangya Medical Laboratory, Central South University, Changsha, China

Abstract

Aim: To explore the appropriate triage methods for women infected with high-risk human papillomavirus (hrHPV). Materials & methods: A total of 424 out of 872 hrHPV-infected women were divided into cervicitis (n = 123), cervical intraepithelial neoplasia grade 1 (CIN1; n = 89), CIN2 (n = 72), CIN3 (n = 87) and cervical cancer (n = 53) groups. Results: The sensitivity/specificity of ZNF582m, PAX1m and liquid-based cytology (LBC) for hrHPV-infected women with transformation zone 3 CIN3+ was 83.9/93.1, 77.4/90.6 and 80.6/58.5%, respectively. The ZNF582m/ PAX1m test had a higher specificity than LBC (p < 0.001) and similar sensitivity to that observed for LBC (p > 0.05). ZNF582m/ PAX1m improved the positive predictive value of CIN3+ (64.7/60.0%) in low-grade LBC (negative predictive value: 91.7/88.7%). Conclusion: ZNF582m was superior to PAX1m and LBC tests in detecting CIN3+ in hrHPV-infected women.

Funder

Provincial and ministerial joint projects of the National Health Commission of China

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fon-2021-1625

Reference41 articles.

1. The natural history of human papillomavirus infection

2. 2019 ASCCP Risk-Based Management Consensus Guidelines for Abnormal Cervical Cancer Screening Tests and Cancer Precursors

3. Clinical implications of (epi)genetic changes in HPV-induced cervical precancerous lesions

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