<i>GBAP1</i> polymorphisms (rs140081212, rs1057941 and rs2990220) contribute to reduced risk of gastric cancer-Reference-Cited by-同舟云学术

GBAP1 polymorphisms (rs140081212, rs1057941 and rs2990220) contribute to reduced risk of gastric cancer

Published:2022-05 Issue:15 Volume:18 Page:1861-1872
ISSN:1479-6694
Container-title:Future Oncology
language:en
Short-container-title:Future Oncology

Author:

Duan Xianglong¹²,Shan Liang²,Shi Shuai³,Xu Boyu³,Chen Xin³,Di Jinqin³,Chen Bopeng³,Li Xiaoqing⁴^ORCID,Liu Sida³,Wang Yuhe¹,Yang Wei¹

Affiliation:

1. Key Laboratory of Molecular Mechanism and Intervention Research for Plateau Diseases of Tibet Autonomous Region, School of Medicine, XizangMinzu University, Xianyang, Shaanxi, 712082, China

2. Department of Rehabilitation Medicine, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, 710068, China

3. Second Department of General Surgery, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, 710068, China

4. Department of Dermatology, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, 710068, China

Abstract

Aim: This study was designed to evaluate the contribution of GBAP1 variants to gastric cancer (GC) risk in a Chinese Han population. Methods: The genotypes of GBAP1 polymorphisms were detected using the Agena MassARRAY platform. Logistic regression analysis was used to calculate odds ratios (ORs) and 95% CIs. Results: GBAP1 rs140081212 (OR = 0.51, p = 4.50 × 10-07), rs1057941 (OR = 0.48, p = 1.19 × 10-08) and rs2990220 (OR = 0.46, p = 7.34 × 10-09) contribute to reduced GC risk, especially gastric adenocarcinoma. Interestingly, the contribution of GBAP1 variants to GC susceptibility was associated with age, sex, BMI, smoking and drinking. Conclusion: This research suggested that GBAP1 polymorphisms might provide a protective effect against GC occurrence in a Chinese Han population.

Funder

Innovation Capability Support Program of Shaanxi Province

Scientific Research Program Funded by Shaanxi Provincial Education Department

National Natural Science Foundation of China

The Key Research and Development Program of Shaanxi Province

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fon-2021-0973

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