The significant role of a functional polymorphism in the NF-κB1 gene in breast cancer: evidence from an Iranian cohort

Author:

Alidoust Maryam12ORCID,Shamshiri Asma Khorshid12ORCID,Tajbakhsh Amir32ORCID,Gheibihayat Seyed Mohammad4ORCID,Mazloom Seyed Mostafa5ORCID,Alizadeh Farzaneh2ORCID,Pasdar Alireza167ORCID

Affiliation:

1. Department of Medical Genetics & Molecular Medicine, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran

2. Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz 17345-1583, Iran

3. Student Research Committee, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran

4. Department of Medical Biotechnology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd 8915167426, Iran

5. Department of Animal Science, Ferdowsi University of Mashhad, Mashhad 91779-48944, Iran

6. Division of Applied Medicine, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK

7. Bioinformatics Research Group, Mashhad University of Medical Sciences, Mashhad, Iran

Abstract

Aims: Breast cancer (BC) is one of the most common cancers among women. The influence of genetic variations on BC risk has been thus far assessed via genome-wide association studies. NF-κB has been recognized as a major player in BC progression. In this study, the association between rs28362491 and BC was evaluated in a population from northeastern Iran. Materials & methods: This study was conducted on 476 patients with BC and 524 healthy controls. The genotyping method used was an amplification-refractory mutation system. Results: The INS/DEL genotype conferred a statistically significant increased risk in patients in comparison with controls. Additionally, in the recessive model, INS/INS + INS/DEL versus DEL/DEL was statistically significant (OR = 0.34; 95% CI: 0.12–0.96; p = 0.042). Conclusion: This study found that rs28362491, as a susceptibility genetic factor, may affect BC risk in the Iranian population.

Funder

Mashhad University of Medical Sciences

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

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