The diagnostic value of soluble TIM-3 in oral squamous cell carcinoma-Reference-Cited by-同舟云学术

The diagnostic value of soluble TIM-3 in oral squamous cell carcinoma

Published:2022-04 Issue:11 Volume:18 Page:
ISSN:1479-6694
Container-title:Future Oncology
language:en
Short-container-title:Future Oncology

Author:

Lu Kairui¹,Ma Hongtao²³⁴⁵,Wang Tingting⁶,Huang Yongsong⁶,Ru Meilin⁷^ORCID

Affiliation:

1. Department of General Dentistry, The Third People’s Hospital of Bengbu, Bengbu, Anhui, China

2. Department of General Dentistry, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

3. College of Stomatology, Shanghai Jiao Tong University, Shanghai, China

4. National Center for Stomatology; National Clinical Research Center for Oral Diseases, Shanghai, China

5. Shanghai Key Laboratory of Stomatology, Shanghai, China

6. Department of Stomatology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China

7. Community Health Service Center of Huajing Town, Xuhui District, Shanghai, China

Abstract

Objective: To evaluate the soluble TIM-3 (sTIM-3) expression level in oral squamous cell carcinoma (OSCC) and determine its clinical diagnostic potential. Methods: The sTIM-3 and squamous cell carcinoma antigen (SCCAg) levels of 199 OSCC patients and 107 healthy individuals were assessed using an enzyme-linked immunosorbent assay and their individual and combined efficiency rates were compared. Results: The results showed higher sTIM-3 and SCCAg levels in the OSCC patients and better diagnostic potential for a combination of these markers than for their individual assessments, as well as positive correlation of sTIM-3 levels with clinicopathological factors. Conclusion: sTIM-3 is a potential novel and readily accessible OSCC biomarker, which in combination with SCCAg expression level might better diagnose OSCC patients.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fon-2021-1379

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