An overview of reviews with network meta-analyses comparing disease-modifying therapies for relapsing multiple sclerosis

Author:

Drudge Christopher1ORCID,Samjoo Imtiaz A1ORCID,Brennan Róisín2,Badgujar Lohit3ORCID,Khurana Vivek3,Tiwari Santosh3,Adlard Nicholas4ORCID,Banhazi Judit4

Affiliation:

1. Value & Evidence, EVERSANA™, Burlington, Ontario, Canada

2. Novartis Corporate Center Dublin, Dublin, Ireland

3. Novartis Healthcare Private Limited, Hyderabad, India

4. Novartis Pharma AG, Basel, Switzerland

Abstract

Aim: An overview of published systematic reviews (SRs) with integrated network meta-analyses (NMAs) comparing disease-modifying therapies (DMTs) for relapsing multiple sclerosis (RMS) was conducted to help inform healthcare decision-making. Methods: We searched Embase, MEDLINE® and Cochrane Database of Systematic Reviews from inception to May 2023. Full-text studies evaluating annualized relapse rate (ARR) and/or confirmed disability progression (CDP) were qualitatively compared. Methodological quality was assessed using SR and NMA questionnaires. Results: Twenty-one SRs with integrated NMAs were included. Studies varied in their conduct and reporting of the SR, the included primary evidence, treatments, and cross-trial heterogeneity assessment and their conduct and reporting of NMAs. The quality of the studies was variable. Monoclonal antibody therapies were determined to be the most efficacious DMTs for reducing ARR and delaying CDP. Conclusion: Future analyses should carefully consider and clearly report methods and results to permit accurate interpretation of NMA findings and better inform decision-making.

Funder

Novartis Pharma AG

Publisher

Future Medicine Ltd

Subject

Neurology (clinical),Neurology

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