Accumulation of amino-polyvinyl alcohol-coated superparamagnetic iron oxide nanoparticles in bone marrow: implications for local stromal cells

Author:

Schulze Frank12,Gramoun Azza34,Crowe Lindsey A3,Dienelt Anke15,Akcan Tugba1,Hofmann Heinrich6,Vallée Jean-Paul3,Duda Georg N15,Ode Andrea15

Affiliation:

1. Julius Wolff Institute, Charité – Universitätsmedizin Berlin, 13353 Berlin, Germany

2. Berlin-Brandenburg School for Regenerative Therapies, Charité – Universitätsmedizin Berlin, 13353 Berlin, Germany

3. Department of Radiology, Geneva University Hospitals & University of Geneva, 1205 Geneva, Switzerland

4. Department of Oral Biology, Faculty of Oral & Dental Medicine, Cairo University, Cairo, Egypt

5. Berlin-Brandenburg Center for Regenerative Therapies, Charité – Universitätsmedizin Berlin, 13353 Berlin, Germany

6. Laboratory of Powder Technology, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland

Abstract

Aims: First, it will be investigated if amino-polyvinyl alcohol-coated superparamagnetic iron oxide nanoparticles (A-PVA-SPIONs) are suitable for MRI contrast enhancement in bone marrow. Second, the impact of A-PVA-SPION exposure in vivo on the viability and key functions of local bone marrow stromal cells (BMSCs) will be investigated. Material & methods: Animals were systemically injected with A-PVA-SPIONs, followed by a 7-day survival time. Accumulation of A-PVA-SPIONs was confirmed by MRI, histology and inductively coupled plasma optical emission spectrometry. BMSCs were isolated from bone marrow for in vitro assessment of their viability and regenerative key functions. Results: In this study, A-PVA-SPIONs were found to accumulate in bone marrow and increase the BMSCs’ metabolic activity and migration rate. Conclusion: A-PVA-SPIONs appear suitable for contrast enhancement in bone marrow while our data suggest an influence on the BMSCs biology that necessitates future research.

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

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