Copeptin: a neuroendocrine biomarker of COVID-19 severity-Reference-Cited by-同舟云学术

Copeptin: a neuroendocrine biomarker of COVID-19 severity

Published:2022-06 Issue:8 Volume:16 Page:589-597
ISSN:1752-0363
Container-title:Biomarkers in Medicine
language:en
Short-container-title:Biomarkers in Medicine

Author:

Hammad Reham¹^ORCID,Elshafei Ahmed²^ORCID,Khidr Emad Gamil²^ORCID,El-Husseiny Ahmed A²^ORCID,Gomaa Maher H²^ORCID,Kotb Hend G³^ORCID,Eltrawy Heba H⁴^ORCID,Farhoud Hesham⁵

Affiliation:

1. Department of Clinical Pathology, Faculty of Medicine (Girls), Al-Azhar University, Cairo, 11884, Egypt

2. Biochemistry & Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, 11884, Egypt

3. Internal Medicine Department, Faculty of Medicine (Girls), Al-Azhar University, Cairo, 11884, Egypt

4. Chest Diseases Department, Faculty of Medicine (Girls), Al-Azhar University, Cairo, 11884, Egypt

5. Orthopedic Surgery Department, Dean of Faculty of Medicine (Girls), Al-Azhar University, Cairo, 11884, Egypt

Abstract

Aim: To investigate the change in a serum level of copeptin, a neuroendocrine biomarker, in differentiating grades of COVID-19 severity on admission time and to find its diagnostic potential. Materials & Methods: 160 COVID-19 patients were classified according to disease severity into 80 mild to moderate and 80 severe patients. Serum copeptin level was assessed by ELISA on their admission time. Besides, serum CRP, ferritin and D-dimer were estimated. Results: Severe COVID-19 patients showed higher serum copeptin level in comparison to mild to moderate cases, with diagnostic potential to distinguish disease severity with 93.33% sensitivity and 100% specificity at cutoff value >18.5 Pmol/l. Conclusion: Serum copeptin was remarkably increased with COVID-19 severity with reasonable differentiation potential for recently admitted patients.

Publisher

Future Medicine Ltd

Subject

Biochemistry (medical),Clinical Biochemistry,Drug Discovery

Link

https://www.futuremedicine.com/doi/pdf/10.2217/bmm-2021-1100

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