Accuracy of cytokeratin 19 fragment in the diagnosis of bladder cancer-Reference-Cited by-同舟云学术

Accuracy of cytokeratin 19 fragment in the diagnosis of bladder cancer

Published:2022-02 Issue:3 Volume:16 Page:197-216
ISSN:1752-0363
Container-title:Biomarkers in Medicine
language:en
Short-container-title:Biomarkers in Medicine

Author:

Zhu Rui-Jue¹²,Zhou Jie¹²,Liang Pan-Qiao¹²,Xiang Xiao-Xiu¹²,Ran Jie¹²,Xie Tian-Ao¹²,Guo Xu-Guang¹²³⁴^ORCID

Affiliation:

1. Department of Clinical Laboratory Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China

2. Department of Clinical Medicine, The Third Clinical School of Guangzhou Medical University, Guangzhou, 511436, China

3. Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China

4. Key Laboratory of Reproduction & Genetics of Guangdong Higher Education Institutes, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China

Abstract

Aim: CYFRA21-1 is a biomarker of cancer and has a promising future in the diagnosis of bladder cancer. The purpose of this study was to assess the diagnostic accuracy of CYFRA21-1 for bladder cancer. Methods: We included articles from the Cochrane Library, Web of Science, PubMed and Embase. Meta-DiSc 1.4 and Stata 12.0 were used for data analysis. Results: Twenty-eight articles were analyzed, and the results are as follows: sensitivity, specificity, PLR, NLR, DOR and AUC were 0.69 (95% CI [0.67, 0.71]), 0.81 (95% CI [0.80, 0.83]), 5.99 (95% CI [4.42, 8.11]), 0.31 (95% CI [0.25, 0.38]), 24.58 (95% CI [15.15, 39.89]) and 0.8917, respectively. Conclusion: CYFRA21-1 has a high diagnostic efficiency for bladder cancer.

Funder

The Third Clinical School of Guangzhou Medical University

Publisher

Future Medicine Ltd

Subject

Biochemistry (medical),Clinical Biochemistry,Drug Discovery

Link

https://www.futuremedicine.com/doi/pdf/10.2217/bmm-2021-0754

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