Effect of low-flux and high-flux dialysis membrane on plasma concentrations of cardiac troponin I-Reference-Cited by-同舟云学术

Effect of low-flux and high-flux dialysis membrane on plasma concentrations of cardiac troponin I

Published:2021-11 Issue:16 Volume:15 Page:1479-1486
ISSN:1752-0363
Container-title:Biomarkers in Medicine
language:en
Short-container-title:Biomarkers in Medicine

Author:

Šavuk Ana¹^ORCID,Svaguša Tomo²^ORCID,Trkulja Vladimir³^ORCID,Radeljak Andrea⁴^ORCID,Rudan Diana²^ORCID,Kudumija Boris⁵^ORCID,Doko Slava⁶^ORCID,Kovačević Lucija⁷^ORCID,Pezić Mija M⁸^ORCID,Ćorić Valentina⁸^ORCID,Matić Ivica⁹^ORCID,Prkačin Ingrid¹⁰^ORCID

Affiliation:

1. Department of Nephrology & Dialysis, Clinical Hospital Dubrava, Zagreb, Croatia

2. Department of Cardiovascular Diseases, Clinical Hospital Dubrava, Zagreb, Croatia

3. School of Medicine, University of Zagreb, Zagreb, Croatia

4. Department of Medical Biochemistry & Laboratory Medicine, Reference Center of The Ministry of Health of The Republic of Croatia for the Development & Application of Biological Reference Intervals for Medical Biochemical Tests, Merkur University Hospital, Zagreb, Croatia

5. Dialysis Department, Avitum Polyclinic, Zagreb, Croatia

6. Public Health Centre Zagreb-East, Zagreb, Croatia

7. Department of Radiology, Clinical Hospital Center Zagreb, Zagreb, Croatia

8. Department of Internal Medicine, General Hospital Vinkovci, Vinkovci, Croatia

9. School of Nursing Mlinarska, Zagreb, Croatia

10. Department of Internal Medicine, Clinical Hospital Merkur, Zagreb, Croatia

Abstract

Aim: Cardiac troponin I (cTnI) concentration stability during dialysis have not been fully elucidated. The aim is to evaluate the effect of a single dialysis session on plasma cTnI. Patients & methods: From 122 consecutive anuric adult patients (75 [61.5%] men, age 27–86 years, median 67) on chronic hemodialysis blood samples for cTnI measurement were taken before and after a dialysis. Results: Dialysis had no effect on high-flux membranes (geometric means ratio = 0.99, 0.94–1.05, df 119, t = -0.19, multiplicity adjusted p = 0.847), but cTnI levels were higher after dialysis in patients on low-flux membranes (geometric means ratio = 1.14, 1.02–1.27, df 119, t = 2.59, adjusted p = 0.021). Conclusion: Dialysis session using low-flux membranes might increase the plasma cTnI.

Publisher

Future Medicine Ltd

Subject

Biochemistry (medical),Clinical Biochemistry,Drug Discovery

Link

https://www.futuremedicine.com/doi/pdf/10.2217/bmm-2021-0149

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