Blood Bcl-2 levels to predict the mortality of septic patients

Author:

Lorente Leonardo1ORCID,Martín María M2,Ortiz-López Raquel3,Pérez-Cejas Antonia1,Ferrer-Moure Carmen1,González Oswaldo1,Jiménez Alejandro4,González-Rivero Agustín F5

Affiliation:

1. Intensive Care Unit, Hospital Universitario de Canarias, Ofra, s/n. La Laguna, Tenerife, 38320, Spain

2. Intensive Care Unit, Hospital Universitario Nuestra Señora Candelaria, Crta Rosario s/n. Santa Cruz Tenerife, 38010, Spain

3. Intensive Care Unit, Hospital General de La Palma, Buenavista de Arriba s/n, Breña Alta, La Palma, 38713, Spain

4. Research Unit, Hospital Universitario de Canarias, Ofra, s/n. La Laguna, Tenerife, 38320, Spain

5. Department of Laboratory, Hospital Universitario de Canarias. Ofra, s/n. La Laguna, Santa Cruz de Tenerife, 38320, Spain

Abstract

Aim: To determine whether blood concentrations of Bcl-2 during the 1st week of sepsis could help predict mortality. Methods: Serum Bcl-2 concentrations were determined at the 1st, 4th and 8th days of sepsis diagnosis. Results: Thirty-day surviving patients (n = 168) showed higher serum Bcl-2 levels at the 1st (p = 0.002), 4th (p < 0.001) and 8th days (p < 0.001) of sepsis diagnosis than non-surviving patients (n = 91). An association between serum Bcl-2 concentrations at the 1st (p = 0.003), 4th (p < 0.001) and 8th days (p = 0.01) and 30-day mortality after controlling for diabetes mellitus, Sepsis-related Organ Failure Assessment, lactic acid and age was found in the multiple logistic regression analysis. Conclusions: The novel finding is that blood Bcl-2 concentrations at any time in the 1st week of sepsis are associated with mortality.

Funder

Instituto de Salud Carlos III (Madrid, Spain) and co-financed with Fondo Europeo de Desarrollo Regional

Publisher

Future Medicine Ltd

Subject

Biochemistry (medical),Clinical Biochemistry,Drug Discovery

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