Affiliation:
1. Department of Surgery & Anaesthesia, University of Otago, Wellington, New Zealand
2. Wellington Cardiovascular Research Group, University of Otago, Wellington, New Zealand
3. School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand
4. Department of Cardiology, Wellington Regional Hospital, Wellington, New Zealand
Abstract
Aim: This study investigated an optimal extracellular matrix (ECM) biomarker panel for measurement in acute myocardial infarction (AMI). Materials & methods: Blood samples were collected from 12 healthy volunteers, and from 23 patients during hospital admission (day 1–3) and 6 months following AMI. Protein assays measured: FGFb, MMP-2, -3, -8, -9, osteopontin, periostin, PINP, TGF-β1, TIMP-1, -4 and VEGF. Results: When compared with healthy levels, seven ECM biomarkers were significantly altered in AMI patients, and six of these biomarkers displayed stable expression during hospital admission. Clinical characteristics and baseline cardiac function were not well correlated with ECM biomarkers. Conclusion: We suggest, MMP-2, MMP-3, MMP-8, MMP-9, periostin, PINP and TIMP-1 may be useful ECM biomarkers for future studies in AMI patients.
Funder
Wellington Medical Research Foundation
Subject
Biochemistry (medical),Clinical Biochemistry,Drug Discovery