Role of miRNAs as biomarkers of COVID-19: a scoping review of the status and future directions for research in this field-Reference-Cited by-同舟云学术

Role of miRNAs as biomarkers of COVID-19: a scoping review of the status and future directions for research in this field

Published:2021-12 Issue:18 Volume:15 Page:1785-1795
ISSN:1752-0363
Container-title:Biomarkers in Medicine
language:en
Short-container-title:Biomarkers in Medicine

Author:

Visacri Marília B¹^ORCID,Nicoletti Aline S¹^ORCID,Pincinato Eder C²^ORCID,Loren Pía³^ORCID,Saavedra Nicolás³^ORCID,Saavedra Kathleen³^ORCID,Salazar Luis A³^ORCID,Moriel Patricia⁴^ORCID

Affiliation:

1. Department of Pharmacology, School of Medical Sciences, University of Campinas, Campinas, 13083-887, Brazil

2. Department of Clinical Pathology, School of Medical Sciences, University of Campinas, Campinas, 13083-887, Brazil

3. Center of Molecular Biology & Pharmacogenetics, Scientific & Technological Bioresource Nucleus, Universidad de La Frontera, Temuco, 4811230, Chile

4. Faculty of Pharmaceutical Sciences, University of Campinas, Campinas, 13083-871, Brazil

Abstract

Aim: miRNAs are potential biomarkers of several diseases. This review aimed to identify the miRNAs that could serve as biomarkers of COVID-19. Materials & methods: A literature search of nine databases was carried out for studies published before 13 June 2021 that described dysregulated miRNAs in cells or animals infected by SARS-CoV-2 or in patients with COVID-19. Two independent reviewers selected the studies and extracted data; disagreements were resolved by a third reviewer. Results: Twenty studies were included in this scoping review; results suggested that miR-21-5p, miR-146a, miR-126-3p, miR-144 and miR-155 are the most important dysregulated miRNAs that could serve as biomarkers for diagnosing and indicating the severity of COVID-19. miRNAs appear to play key roles in viral replication, proliferation of infected cells, immune response, inflammation and cardiovascular dysfunction. Conclusion: This review provides insights into the role of miRNAs as biomarkers in COVID-19 and the current status and future directions for research in this field.

Funder

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brasil

Publisher

Future Medicine Ltd

Subject

Biochemistry (medical),Clinical Biochemistry,Drug Discovery

Link

https://www.futuremedicine.com/doi/pdf/10.2217/bmm-2021-0348

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