Thiols and disulfide levels are correlated with TIMI thrombus grade in non-ST elevation myocardial infarction patients-Reference-Cited by-同舟云学术

Thiols and disulfide levels are correlated with TIMI thrombus grade in non-ST elevation myocardial infarction patients

Published:2022-03 Issue:4 Volume:16 Page:233-240
ISSN:1752-0363
Container-title:Biomarkers in Medicine
language:en
Short-container-title:Biomarkers in Medicine

Author:

Özbiçer Süleyman¹^ORCID,Yüksel Gülhan¹^ORCID,Urgun Örsan D¹^ORCID,Neşelioğlu Salim²^ORCID,Erel Özcan²^ORCID

Affiliation:

1. Department of Cardiology, University of Health Sciences Adana City Training & Research Hospital, Adana, Turkey

2. Department of Clinical Biochemistry, Yıldırım Beyazıt University, Medicine Faculty, Ankara, Turkey

Abstract

Aim: We investigated the relationship between thrombolysis in myocardial infarction (TIMI) thrombus grade and thiol/disulfide levels. Materials & methods: 182 non-ST elevation myocardial infarction (NSTEMI) patients were divided into two groups; TIMI grade 0 patients who do not have any visible thrombus in their culprit vessels, and TIMI thrombus grade 1–5 patients. Results: Native and total thiol levels and disulfide to thiol ratio were higher in the low thrombus group. In addition, thrombus grade was positively correlated with disulfide to native and total thiol ratio and negatively with native and total thiol levels in NSTEMI patients. Conclusion: We can assert that thiol levels tend to decrease and the disulfide to thiol ratio increase, with the increasing thrombus burden in NSTEMI patients.

Publisher

Future Medicine Ltd

Subject

Biochemistry (medical),Clinical Biochemistry,Drug Discovery

Link

https://www.futuremedicine.com/doi/pdf/10.2217/bmm-2021-0659

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